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Eziprod 200(p)



PACK:  Strip of 10 tablets.

Categories: ,

Product Description

COMPOSITION:  Each Tablet  contains :-

Cefpodoxime      200 mg

M.O.A. :

It works by interfering with the formation of the outer covering (cell wall) of bacteria so that the wall ruptures and results in the death of the bacteria.


Cefpodoxime is taken up in the intestine and is hydrolysed to the active metabolite cefpodoxime. When cefpodoxime proxetil is administered orally to fasting subjects as a tablet corresponding to 100 mg of cefpodoxime, 51.5% is absorbed and absorption is increased by food intake. The volume of distribution is 32.3 L and peak levels of cefpodoxime occur 2 to 3 hrs after dosing. The maximum plasma concentration is 1.2 mg/L and 2.5 mg/L after doses of 100 mg and 200 mg respectively. Following administration of 100 mg and 200 mg twice daily over 14.5 days, the plasma pharmacokinetic parameters of cefpodoxime remain unchanged.

Serum protein binding of cefpodoxime,  40% principally to albumin. This binding is non saturable in type.

Concentrations of cefpodoxime in excess of the minimum inhibitory levels (MIC) for common pathogens can be achieved in lung parenchyma, bronchial mucosa, pleural fluid, tonsils, interstitial fluid and prostate tissue.

As the majority of cefpodoxime is eliminated in the urine, the concentration is high. (Concentrations in 0-4, 4-8, 8-12 hr fractions after a single dose exceed MIC90 of common urinary pathogens). Good diffusion of cefpodoxime is also seen into renal tissue, with concentrations above MIC90 of the common urinary pathogens, 3-12 hrs after an administration of a single 200 mg dose (1.6-3.1μg/g). Concentrations of cefpodoxime in the medullary and cortical tissues is similar.

Studies in healthy volunteers show median concentrations of cefpodoxime in the total ejaculate 6-12 hrs following administration of a single 200 mg dose to be above the MIC90 of N. gonorrhoeae.

The main route of excretion is renal, 80% is excreted unchanged in the urine, with an elimination half-life of approx 2.4 hours.

 INDICATION  : Respiratory tract infection, urinary tract infection, Skin infection, Otitis media, Uncomplicated gonorrhea

DOSAGE: As directed by the physician

SIDE EFFECTS: Hypersenstivity, skin rash, nausea, diarrhoea, vomiting, abdominal pain.


1 Cepodem Ranbaxy pharma 139/10
2 Gudcef Mankind 109/10
3 Podoxim Wockhardt 130.50/10
4 Doxcef Lupin 96/10
5 Swich Alkem Lab 135/10


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