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DR RAB D

DRRAB D

₹18.00

PACK:  Strip of 10 tablets.

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Product Description

COMPOSITION : Each Tablet  contains :-

RABEPRAZOLE   20 mg

DOMPERIDONE   10 mg

M.O.A : Rabeprazole belongs to class of medications called proton pump inhibitors. It blocks the activity of the proton pumps in the stomach wall that produce acid, thereby reducing the amount of acid produced in the stomach.

Domperidone belongs to a class of medicines known as anti-emetics. Domperidone acts by helping food move faster through the food pipe, stomach and gut; thus normalising the digestion process.

PHARMACOLOGY:

Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cells.

PHARMACOKINETICS

Absorption

max is 2 to 5 h. Oral bioavailability is approximately 52%.

Distribution

Protein binding is 96.3%.

 Metabolism

Extensively metabolized in liver by CYP3A to sulphone metabolite and CYP2C19 to desmethyl rabeprazole. Thioether and sulphone metabolites are formed by reduction of rabeprazole. These metabolites do not have significant antisecretory activity. CYP2C19 exhibits genetic polymorphism caused by deficiency in some subpopulations (white patients, 3% to 5%; Asian patients, 17% to 20%).

Elimination

Plasma half-life is 1 to 2 h. Eliminated in urine (90% as thioether carboxylic acid, glucuronide, and mercapturic acid); remainder recovered in feces. No unchanged drug recovered.

INDICATION  : The  management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.

 DOSAGE:  As directed by the physician.

SIDE EFFECTS:  Irritability, Dry mouth, Headache, Loss of interest in sex, Breast pain or tenderness, Abnormal heart rhythm, Drowsiness, Abnormal milk discharge from breast, Diarrhoea.

SIMILAR PRODUCTS

Sr No SIMILAR PRODUCTS COMPANY MRP / Tab
1 Rabifin-D Ind Swift Lab 11.7/10
2 Rabegard-D Mankind 65/10
3 Rabicer-D Biochem Pharma 18.75/10

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