COMPOSITION :Each tablet contains :
- Metformin belongs to class of medications called antidiabetics.It decreases the amount of glucose absorbed from the food and the amount ofglucose made by liver. Metformin also increases the body’s response to insulin (a natural substance that controls the amount of glucose in the blood).
- Gliclazide belongs to a blood sugar lowering group of medicines called sulfonylurea. Gliclazide increases the amount of insulin released by the pancreas, and thereby decreases the blood sugar level.
Gliclazide reduces blood glucose levels by correcting both defective insulin secretion and peripheral insulin resistance.This occurs by closure of K+ channels in β -cells of pancreas. Subsequently, Ca2+ channel opens leading to increase inintracellular calcium and induction of insulin release. Gliclazide also increases the sensitivity of β-cells to glucose. Gliclazide restores peripheral insulin sensitivity such as decreasing hepatic glucose production and increasing glucose clearance. It has anti-platelet adhesive activity and reduces level of free radicals, thereby preventing vascular complications. Gliclazide has been reported to reduce plasma cholesterol and triglyceride levels after repeated administration. Metformin acts as an antihyperglycaemic agent by improving hepatic and peripheral tissue sensitivity to insulin. It also appears to have beneficial effect on serum lipid levels and so on fibrinolytic activity. Metformin therapy is not associated with increase in body weight.
INDICATION : Type 2 diabetes mellitus.
DOSAGE : As directed by the physician
SIDE EFFECTS : Chest pain, A metallic taste in the mouth, Flushing of skin, Allergic reactions such as skin rash, Indigestion, Abdominal and stomach pain, Nail changes, Accumulation of gas, Constipation and diarrhea, Heart burn, Bloating, Muscle pain, And headache.